Publications
Classic and recent papers: Katzmann 2002 on FLC reference ranges, Rajkumar 2014 IMWG criteria, the BLIMP1-IRF4-XBP1 triad review, and the literature behind every number in the ledger.
Documents Waldeyer 1875 (term coined, attribution disputed), Marshalko 1895 (morphological definition), Fagraeus 1947 (antibody secretion proved), Coons 1955 (fluorescent confirmation).
BLIMP1 regulates UPR components including XBP-1 and ATF6; required for plasmablast to plasma cell maturation. Classic paper in the differentiation hierarchy.
Blimp-1 as master coordinator of plasma cell differentiation; acts upstream of XBP-1; required for terminal differentiation from activated B cell.
XBP1 specifically required for late plasma cell differentiation events; not required for memory B cell development, separating these two fates.
2025 review of Russell bodies (cytoplasmic Ig spherules) and Mott cells (plasma cells with grape-like morular pattern of Ig-filled vacuoles) in myeloma.
Image correspondence demonstrating Russell body accumulation in a light chain myeloma case; clinical context for the morphologic variant.
Identifies CD138/CD31 co-expression as marking long-lived bone marrow plasma cells in primate; supports CD138 (syndecan-1) as the primary IHC marker for plasma cell enumeration.
Reviews how heterogeneous plasma cell populations differ in survival potential and maturity within the bone marrow niche, with implications for vaccine durability and autoimmunity.
Annual review summarizing 2025 key advances in plasma cell biology including niche survival factors, longevity mechanisms, and connections to antibody-mediated immunity.
Multiomics (RNA-seq, ATAC-seq, methylation) on IgM, IgG, IgA ASCs after influenza in mice; each isotype carries a distinct program, proposed as distinct lineages.
Review examining transcriptional, epigenetic, functional, and niche-related heterogeneity within the plasmocyte compartment; argues against treating plasma cells as a uniform population.
Editorial introducing a research topic on ASC maturity and longevity: frames heterogeneity as a spectrum, not a binary long-lived vs short-lived distinction.
Review of new tools to study LLPC: fate-mapping, single-cell barcoding, organ-on-a-chip BM niches, and epigenetic profiling. Frames durable vaccine responses as requiring LLPC establishment in BM. Covers how current adjuvant strategies influence LLPC seeding.
Genome-wide pooled CRISPR screen in differentiated plasma cells; identifies regulators of IgG secretion beyond the canonical XBP1-IRE1alpha UPR axis. Novel hits include metabolic and proteostasis genes. Relevant to the twin because it maps the gene network that sets the secretion rate range (100 to 10,000 mol/s).
Preprint (2023, bioRxiv). Single-cell transcriptomic atlas of human bone marrow plasma cells. Maps maturation states from newly arrived ASCs to long-lived BM plasma cells. Identifies survival pathway activation signatures (NF-kappaB, APRIL signaling, UPR) as maturation markers. Complements Nguyen DC 2025 (PMID 40963623) by providing the transcriptomic architecture behind the secretion rate gradient the twin displays.
Human, clinical. Immunopurification followed by LC-MS to characterise monoclonal Ig from BM plasma cells. Technical method paper; documents that BM plasma cells produce characterisable Ig that can be resolved per cell in clinical samples. Context for the twin: the 150 kDa IgG mass used in the amino acid import derivation (1,323 aa) is consistent with the Ig species this method resolves. Not a source for rates.